Synthetic protein–protein interaction domains created by shuffling Cys 2 His 2 zinc‐fingers
نویسندگان
چکیده
منابع مشابه
Synthetic protein–protein interaction domains created by shuffling Cys2His2 zinc-fingers
Cys2His2 zinc-fingers (C2H2 ZFs) mediate a wide variety of protein-DNA and protein-protein interactions. DNA-binding C2H2 ZFs can be shuffled to yield artificial proteins with different DNA binding specificities. Here we demonstrate that shuffling of C2H2 ZFs from transcription factor dimerization zinc-finger (DZF) domains can also yield two-finger DZFs with novel protein-protein interaction sp...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2006
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb4100053